UK is now 42-2 when scoring 80 or more points under Mitchell.
Kentucky darted out to an 11-0 lead in the first 3:53 seconds of the contest.
Pepperdine ended the first half scoring 10 of its final 12 points from the charity stripe.
UK began the second half on an 8-0 run to extend its lead to 45-33 with 17:03 remaining.
UK just missed on setting a new season high for second half shooting, hitting 58.3 percent (16-of-27) from the field. The season high is 59.4 percent vs. Miami Ohio.
Four Wildcats reached double-figures for the fifth time this season.
UK won the turnover battle 22-14 and is 102-27 under Mitchell when committing fewer turnovers than its opponent.
The Wildcats extended their streak of consecutive games with a triple to 302.
Kentucky has forced double-digit miscues in 127 consecutive games. The Cats are 94-33 during that span.
UK has forced 20-plus turnovers in all 10 games this season and in 39 of its last 45 games, dating back to the start of last season.
Individual Notes
Junior DeNesha Stallworth led the Wildcats in scoring and tied a season high with 17 points, including 13 points in the second half.
She reached double figures for the seventh straight game and eighth time this year.
Sophomore Bria Goss recorded a season-high 16 points on 5-of-11 shooting from the field, including 5-of-5 from the charity stripe.
Goss reached double-figures for the sixth time this season.
Grabbed a game- and season-high four steals.
Senior A'dia Mathies reached double digits for the eighth time this season with 13 points, passing Sara Potts (2001-05) for No. 6 on the school's UK's all-time scoring list (1,565).
With one steal, she tied Patty Jo Hedges (1979-83) at No. 4 on UK's all-time steals chart with 272.
Mathies' four made field goals moved her into the top-10 all-time in career field goals made with 552.
She moved up to No. 7 on the career field goal attempts chart with 1,320, passing Jodie Whitaker (1985-89)
Mathies has now attempted 358 career 3-pointers, passing Samantha Mahoney (2005-08) for No. 7 all-time.