With the loss, Kentucky drops to 1-2, while Western Kentucky improves to 2-1.
Kentucky leads the series 3-1, including 2-1 in games played in Lexington.
UK is now 12-2 all-time against teams that make up the current alignment of the Sun Belt Conference.
Kentucky returns to action on Saturday, Sept. 22, when the Wildcats open the SEC portion of their schedule at Florida. Kickoff is set for 12:21 p.m. ET and the game will be televised on the SEC Network.
UK now owns a 135-112-4 overall record at Commonwealth Stadium.
The Wildcats played their first overtime game since facing Tennessee in one overtime in 2009.
UK owns a 2-5 all-time record in overtime games.
UK has now held its opponents to a 2-for-7 mark in 2012 on fourth-down conversions.
WKU RB Antonio Andrews rushed 34 times, marking the first UK opponent to have an individual rush of more than 30 carries since Tennessee’s Montario Hardesty rushed it 39 times on Nov. 28, 2009.
UK threw it 60 times in the game vs. WKU, its first 60-pass attempt game since throwing 62 times vs. in a triple-overtime game against Tennessee in 2007.
Kentucky has had 10 or more receivers haul in a catch in each of its first three outings. UK had 11 different receivers make a catch against Louisville and 10 vs. Kent State. Tonight the Wildcats found 11 different patch catchers against Western Kentucky.
Sophomore QB Maxwell Smith completed 37-of-60 passes for 332 yards, with two touchdowns.
Smith has now had back-to-back 300+ yard games in the air, after throwing for 354 yards in a win over Kent State last week.
He is the first UK QB to throw for 300+ yards in consecutive games since Mike Hartline in a two-game span vs. South Carolina and Georgia in 2010.
Senior WR La'Rod King caught a career-high 10 passes for 84 yards.
Has caught 109 passes in his career to become the 13th player in school history to reach 100 receptions.
Has 1,432 receiving yards in his career to move into 10th place all-time, passing Kevin Coleman (1995-98), Larry Seiple (1964-66) and Jacob Tamme (2004-07).