Jarrod Polson was the first sub off the bench for UK. It is the third time Polson was UK's first sub in.
Kentucky extended its streak of games with a 3-pointer to 833 games, the third-longest streak in the country.
UK shot 40.4 percent from the field, snapping a streak of three-straight games shooting better than 50 pct. from the field.
The Wildcats trailed the Irish 36-25 at the half. It was UK's largest halftime deficit this season.
Kentucky is 0-2 when trailing at the half this season.
Notre Dame's 20-point second half lead was the largest deficit UK has faced this season.
This was only the second double-figure loss in Calipari era. The other was against UConn in the 2010 Maui Invitational against UConn, 84-67. Kentucky bounced back from that loss to advance to the school's 14th Final Four.
UK's 50 points were the fewest points in the Calipari Era. The previous low was 55 against UConn in the 2011 Final Four.