Doron Lamb got the first score of the game at 19:12 on runner in the lane.
Kentucky never trailed in the first half.
The Wildcats gradually built leads as large as 15 points at 36-21 and 38-23.
UK went into the locker room with an 11-point lead, 40-29.
The key stat for the Cats in the opening period was eight offensive rebounds that led to a 12-2 advantage in second-chance points.
John Jenkins, who scored a career-high 32 points vs. Kentucky in Nashville, did not get his first basket until the 17:00 mark of the second half. (Jenkins came on strong in the second half and finished with 16.)
Vanderbilt was within 46-42 at the 14:42 mark when UK went on a 9-0 run for a 55-42 cushion.
The Commodores responded with an 18-4 run and got their first lead of the game at 60-59 with 4:25 remaining on a driving layup by Lance Goulbourne.
The teams were separated by no more than three points in the final eight minutes of the game.
Darius Miller put the Wildcats ahead 61-60 with a driving banker at 2:50, UK’s final basket of the game.
Jeffery Taylor put VU ahead 62-61 on a layup at 2:30.
Has scored in double figures in 24-consecutive games and 28 of 29 games this season. It’s the longest streak since Jodie Meeks had 32-straight double-figure games in 2008-09.
Knight made one three-point shot tonight, his 68th of the season, tying the UK freshman record for three-pointers set by Rex Chapman in 1986-87.
Darius Miller made 5-of-9 shots en route to 12 points. He added two steals.
Josh Harrellson had eight points on 4-of-6 shooting. He added nine points and four blocked shots.
Harrellson was honored before the game during Senior Night activities as the lone senior on the 2010-11 squad. Following tradition, Harrellson was presented with a framed jersey and “My Old Kentucky Home” was sung.