Kentucky improves to 27-1, 13-0 in the Southeastern Conference, while Mississippi State falls to 19-9, 6-7.
The Wildcats are 88-20 all-time against Mississippi State and 32-12 against Mississippi State in Starkville.
UK is now 898-251 in SEC regular season action.
The Wildcats are riding a 19-game winning streak and have won seven straight on the road. The 19-game streak ties for the longest streak in the Calipari era with the 19-0 start by the 2009-10 squad. The last Wildcat team to win seven-straight on the road in SEC was the 2002-03 team that went 8-0.
Kentucky has won its first 13 in league play, the best SEC start for the Wildcats since the 2002-03 team went 16-0.
UK returns to action on Saturday, hosting Vanderbilt. Tip-off is scheduled for noon ET and the game will be televised on CBS.