Kentucky is 15-0 while Louisville is 10-4, ending a five-game win streak by the Cardinals.
Kentucky's 15-0 start is its best since the 1969-70 squad opened with 15 consecutive wins.
This is the fifth time in school history that the Wildcats have begun a season with at least 15 straight wins.
This was the 600 th game of Coach John Calipari's career. He has tallied a 460-140 (.767) record.
John Calipari's 15-0 start is the best start by a UK coach in his augural season in UK history.
This is the seventh time in John Calipari's collegiate coaching career that he has had a winning streak of at least 15 games.
Kentucky leads the Louisville series, 27-14.
The Wildcats are 165-70 all-time against the current membership of the BIG EAST Conference, including an earlier win this season against Connecticut.
Today's attendance of 24,479 is a Rupp Arena attendance record. The previous mark was 24,468 earlier this season vs. North Carolina.
After a mid-week open date, the Wildcats open Southeastern Conference action on Sat. Jan. 9 at home against Georgia. The game will tip off at 4 p.m. and will be a regionally syndicated telecast on the SEC Network.
Kentucky scored first when Louisville was assessed a technical foul at the 19:15 mark and Cousins made two foul shots.
Cousins made the first six points of the game, adding a tip-in at 18:58 and a jump hook at 18:22.
Louisville got on the board at 16:26 with a Samardo Samuels free throw, making the score 6-1.
Patterson got the game's first three-pointer at 14:45, giving Kentucky a 9-1 lead. Patterson's 3-pointer extended UK's streak to 726 consecutive games with a 3-pointer, the third-longest streak in the nation.
After 14 misses to open the game, Louisville got its first basket at 10:53 on a Samuels tip-in.
Kentucky led by as many as 13 points at 18-5. The Wildcats had a drought, however, going without a basket for nine minutes, from 12:04 to 3:03.
Louisville used a 7-0 spurt to pull within 18-12.
The Wildcats got a great play with 1:35 to go. After a missed shot was loose in the lane, DeAndre Liggins darted in to tip the ball to Patterson, who swooped in for a dunk, putting UK ahead 25-12.
In the final eight seconds, Louisville got two foul shots from Reginald Delk and three from Preston Knowles to pull within 27-19 at halftime.
UK and UofL combined for 46 points in the first half. This was the lowest scoring first half of the Kentucky-Louisville series since Jan. 21, 1922, when the teams combined for 21 points (UK 11-10; UK went on to win that game, 29-22).
Cousins reached a double-double on a basket with 15:23 remaining.
Trailing 41-33, Louisville went on a 9-0 run, taking its first lead at 42-41 on a Terrence Jennings foul shot with 9:51 on the clock.
UK bounced back with eight straight points, the first six by Wall, as the Wildcats went back up 49-42.
Kentucky increased the lead to 12 at 60-48 with 3:44 to go. Louisville got no closer than seven the rest of the way.
Louisville missed its first 14 field-goal attempts and Kentucky eventually limited the Cardinals to 32.2 percent from the field.
It is the 10 th time in 15 games that UK has held the opponent under 40 percent shooting.
It is Louisville's lowest shooting percentage of the season.
UK won points in the paint, 40-24.
The Wildcats also had a significant advantage in points off turnovers, 26-15.